Application of Ceramic Membrane in Clarification of Antibiotic Fermentation Broth

1. Features of ceramic membrane

The advantages of ceramic membrane compared with polymer separation membrane are:

  1. Good thermal stability, suitable for high temperature and high pressure systems. The trial temperature can generally reach 400 ℃, sometimes as high as 800 ℃.
  2. Good chemical stability, resistance to acids and weak alkalis, and a wide range of pH values.
  3. Strong antimicrobial ability, no biochemical and chemical reaction with general microorganisms.
  4. The ceramic membrane module has high mechanical strength. Ceramic membranes are generally applied in the form of carrier membranes, and the carriers are microporous ceramic materials and porous glass made by high pressure and firing. After coating the membrane, it is fired at a high temperature to make the membrane very strong and not easy to fall off and break.
  5. The clean state is good. It is non-toxic and will not pollute the separated system. Easy to regenerate and clean. When the membrane fouling is blocked, it can be backflushed and flushed, and it can also be chemically cleaned at high temperature.
  6. The pore distribution of the ceramic membrane is narrow and the separation performance is good.
    The disadvantages are: no elasticity, relatively brittle; difficult to process; materials that can be used to make ceramic membranes are relatively scarce; the cost is relatively expensive; under strong alkali conditions, it is easy to be polluted and corroded.

2. Industrialized inorganic ceramic membrane separation system

Generally includes membrane modules, raw material conveying systems, pressure and flow measurement control systems, etc. The main method used is cross-flow filtration. Different from terminal filtration, there are two liquids of permeate and circulating fluid in cross-flow filtration.

3. Antibiotics

The production of antibiotics by fermentation also has the problem of sterilization and filtration. Ceramic membrane separation technology is a suitable choice to replace traditional processes. Compared with the traditional centrifugal method, the ceramic membrane filtration process has the advantages of less energy consumption, high recovery rate, and less eluent required.

Use ceramic membrane to recover penicillin G from fermentation broth. When the cross-flow speed is increased by 2.9 times, the membrane flux is increased by 2 times; when the cross-flow speed is increased by 2.7 times, the membrane flux is increased by 1.8 times, which can save 41% of the time when processing the same amount of liquid.

Someone has studied the method of treating clavulanic acid fermentation broth by cutting two kinds of tubular ceramic ultrafiltration membranes with molecular weights of 15kDa and 150kDa and sheet organic membranes of 20kDa and 5kDa. Experiments show that the 150 kDa ceramic membrane has a higher membrane flux, but the treatment effect cannot replace the traditional solvent extraction process. The 15 kDa ceramic membrane and the 20 kDa organic membrane produce good product quality and at the same time have a good flux. However, the same amount of fermentation broth treated with a 5 kDa ceramic membrane is lower, and the resultant product does not significantly improve the treatment effect of the above two membranes.

At present, some domestic enterprises have applied ceramic membrane separation technology to the production of antibiotics. For example, in the production of glycopeptide antibiotics, ceramic membrane separation technology is used to replace the plate and frame filtration of employees to sterilize the fermentation broth. The clarification effect is due to the plate Frame filtration, after clarification, the fermentation broth can be placed for a longer time, while also reducing labor intensity.

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